Alzheimer's and Lyme Disease References
1993 Jul;4(7):841-8. Links
Neuroreport. 1993 Jul;4(7):840.
Alzheimer's disease--a spirochetosis? (Dr.Miklossy post mortems 14 out of 14
Division of Neuropathology, University of Lausanne, Switzerland.
The aetiology of Alzheimer's disease (AD), which affects a large proportion of
the aged population is unknown and the treatment unresolved. The role of
beta amyloid protein (beta A4), derived from a larger amyloid precursor protein
(APP) in AD is the subject of intense research. Here I report observations that
in 14 autopsy cases with histopathologically confirmed AD, spirochetes were
found in blood and cerebrospinal fluid and, moreover, could be isolated from
brain tissue. Thirteen age-matched control cases were without spirochetes.
Reference strains of spirochetes and those isolated from brains of AD patients,
showed positive immunoreaction with monoclonal antibody against the beta amyloid
precursor protein. These observations suggest that spirochetes may be one of the
causes of AD and that they may be the source of the beta amyloid deposited in
the AD brain.
PMID: 8369471 [PubMed - indexed for MEDLINE
1994 Jun 2;5(10):1201-4. Links
Further ultrastructural evidence that spirochaetes may play a role in the
aetiology of Alzheimer's disease.
Miklossy J, Kasas S, Janzer RC, Ardizzoni F, Van der Loos H. University
Institute of Pathology, Division of Neuropathology, Lausanne,
Recently it was reported that, at autopsy, in neuropathologically confirmed
cases of Alzheimer's disease spirochaetes were found in blood and cerebrospinal
fluid using dark-field microscopy. Moreover, the spirochaetes were isolated and
cultured from brain tissue. We now show, using scanning electron microscopy and
atomic force microscopy that the helically shaped microorganisms isolated and
cultured from the Alzheimer brains possess axial filaments. This indicates that
these microorganisms taxonomically indeed belong to the order Spirochaetales. A
morphometric analysis reinforces this notion.
PMID: 7919164 [PubMed - indexed for MEDLINE]
Miklossy J, Khalili K, Gern L, Ericson RL, Darekar P, Bolle L, Hurlimann J,
Paster BJ. Related Articles, Links
burgdorferi persists in the brain in chronic Lyme neuroborreliosis and may be
associated with Alzheimer disease.
J Alzheimers Dis. 2004 Dec;6(6):639-49; discussion 673-81. PMID: 15665404 [PubMed
- indexed for MEDLINE]
2: Kuntzer T,
Bogousslavsky J, Miklossy J, Steck AJ, Janzer R, Regli F.
Related Articles, Links Borrelia rhombencephalomyelopathy.
Arch Neurol. 1991 Aug;48(8):832-6.
PMID: 1898257 [PubMed - indexed for MEDLINE]
3: Miklossy J, Kuntzer T, Bogousslavsky J, Regli F, Janzer RC. Related
Meningovascular form of neuroborreliosis: similarities between neuropathological
findings in a case of Lyme disease and those occurring in tertiary
Acta Neuropathol (Berl). 1990;80(5):568-72.
PMID: 2251916 [PubMed - indexed for MEDLINE]